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D-cycloserine

D-cycloserine structural formula

Structural formula

Business number 01FD
Molecular formula C3H6N2O2
Molecular weight 102.09
label

(R)-(+)-cycloserine,

D-4-amino-3-isoxazolidinone,

cycloserine,

D-4-amino-3-isoxazolidinone,

4-Amino-3-isoxazolidinone,

(R)-4-Amino-3-isoxazolidinone,

Cycloserine,

Genetic engineering research reagents

Numbering system

CAS number:68-41-7

MDL number:MFCD00005353

EINECS number:200-688-4

RTECS number:NY2975000

BRN number:80798

PubChem number:24892907

Physical property data

1. Properties: Colorless needle-like or leaf-like crystals or amorphous powder

2. Density (g/mL, 25/4℃): Uncertain

3 . Relative vapor density (g/mL, air=1): Uncertain

4. Melting point (ºC): 155-156 (decomposition)

5. Boiling point (ºC, normal Pressure): Uncertain

6. Boiling point (ºC, 5.2kPa): Uncertain

7. Refractive index: Uncertain

8. Flash point ( ºC): Uncertain

9. Specific optical rotation (º): 111 º (C=5, 2N NaOH)

10. Autoignition point or ignition temperature (ºC): Uncertain

11. Vapor pressure (kPa, 25ºC): Uncertain

12. Saturated vapor pressure (kPa, 60ºC): Uncertain

13. Heat of combustion (KJ/mol): Uncertain

14. Critical temperature (ºC): Uncertain

15. Critical pressure (KPa): Uncertain

16. The logarithmic value of the oil-water (octanol/water) partition coefficient: Uncertain

17. The upper explosion limit (%, V/V): Uncertain

18. The lower explosion limit (%, V/V): Uncertain

19. Solubility: Soluble in water, slightly soluble in methanol, ethanol, butanol, propylene glycol, isopropyl alcohol and acetone, hardly soluble or insoluble in toluene, Chloroform, ether, pyridine, benzene and carbon disulfide

Toxicological data

None

Ecological data

None

Molecular structure data

1. Molar refractive index: 22.47

2. Molar volume (cm3/mol): 79.8

3. Isotonic specific volume (90.2K ): 201.9

4. Surface tension (dyne/cm): 40.8

5. Polarizability (10-24cm3): 8.90

Computing chemical data

1. Hydrophobic parameter calculation reference value (XlogP): -1.5

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 3

p>

4. Number of rotatable chemical bonds: 0

5. Number of tautomers: 5

6. Topological molecular polar surface area (TPSA): 64.4

7. Number of heavy atoms: 7

8. Surface charge: 0

9. Complexity: 92.9

10. Isotopic atoms Quantity: 0

11. Determine the number of atomic stereocenters: 1

12. Uncertain number of atomic stereocenters: 0

13. Determine the chemical bond establishment Number of stereocenters: 0

14, Number of uncertain chemical bond stereocenters: 0

15, Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed and stored in a cool, dry place away from light.

Synthesis method

Cycloserine can be prepared by fermentation or direct synthesis. The bacteria produced by the fermentation method is Actinomyces laven-dulae, and the fermentation medium is dextrin, glucose, starch, soybean cake powder, yeast powder, ammonium sulfate, ammonium nitrate, calcium carbonate, sodium chloride, magnesium sulfate and soybean oil, etc. The synthesis method is to react β-aminooxyalanine ethyl ester dihydrochloride with potassium hydroxide to obtain cycloserine through cyclization.

Purpose

Antibiotic drugs. For infections caused by drug-resistant Mycobacterium tuberculosis.

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