thalidomide
Structural formula
| Business number | 013L |
|---|---|
| Molecular formula | C13H10N2O4 |
| Molecular weight | 258.23 |
| label |
Mabofloxacin, Marbofloxacin, thalidomide, Phantamidone, N-(2,6-dioxo-3-piperidinyl)-phthalimide, (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Zeniquine, sedative |
Numbering system
CAS number:50-35-1
MDL number:MFCD00153873
EINECS number:200-031-1
RTECS number:TI4375000
BRN number:None
PubChem number:24278765
Physical property data
1. Properties: light yellow crystalline powder, odorless, tasteless
2. Density (g/mL, 25/4℃): Undetermined
3. Relative Vapor density (g/mL, air=1): Undetermined
4. Melting point (ºC): 269-271°C
5. Boiling point (ºC, normal pressure): Undetermined
6. Boiling point (ºC, 5.2 kPa): Undetermined
7. Refractive index: Undetermined
8. Flash point (ºC): Undetermined
9. Specific rotation (º): Undetermined
10. Autoignition point or ignition temperature (ºC): Undetermined
11. Vapor pressure (kPa, 25 ºC): Not determined
12. Saturated vapor pressure (kPa, 60 ºC): Not determined
13. Heat of combustion (KJ/mol): Not determined Determined
14. Critical temperature (ºC): Undetermined
15. Critical pressure (KPa): Undetermined
16. Oil and water (octanol/water ) Log value of distribution coefficient: Undetermined
17. Explosion upper limit (%, V/V): Undetermined
18. Explosion lower limit (%, V/V): Undetermined Confirm
19. Solubility: Slightly soluble in water (<0.1 g/100 mL at 22 ºC), ethanol, acetone, insoluble in ether and chloroform. 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.6 mg/mL
Toxicological data
None
Ecological data
None
Molecular structure data
1. Molar refractive index: 62.35
2. Molar volume (cm3/mol): 171.7
3. Isotonic specific volume (90.2K ): 496.5
4. Surface tension (dyne/cm): 69.9
5. Polarizability (10-24cm3): 24.71
Calculate chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 1
3. Number of hydrogen bond acceptors: 4
4. Number of rotatable chemical bonds: 1
5. Number of tautomers: 8
6. Topological molecule polar surface area 83.6
7. Number of heavy atoms: 19
8. Surface charge: 0
9. Complexity: 449
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 1
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None
Storage method
This product should be sealed and stored in a dry place away from light.
Synthesis method
None
Purpose
It has a certain effect on various types of leprosy reactions, such as fever, nodular erythema, neuralgia, joint pain, lymphadenopathy, etc., but has a slightly less effective effect on tuberculosis-like leprosy reactions. It has no therapeutic effect on leprosy and can be used together with anti-leprosy drugs to reduce reactions. The preparation is a tablet. This product has strong teratogenic effects and is contraindicated in pregnancy. This medicine should not be used by people without leprosy. Side effects include dry mouth, dizziness, nausea, abdominal pain, etc.
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