Furosemide
Structural formula
| Business number | 016C |
|---|---|
| Molecular formula | C12H11ClN2O5S |
| Molecular weight | 330.74 |
| label |
furosemide, Diuretic, furaniline, sulfonamide, Abdominal acidity, 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid |
Numbering system
CAS number:54-31-9
MDL number:MFCD00010549
EINECS number:200-203-6
RTECS number:CB2625000
BRN number:None
PubChem number:24277714
Physical property data
1. Character:White or off-white crystalline powder, odorless, almost tasteless.
2. Density (g/mL,25/4℃): Undetermined
3. Relative vapor density (g/mL,AIR=1): Undetermined
4. Melting point (ºC): 206
5. Boiling point (ºC,Normal pressure): Undetermined
6. Boiling point (ºC,5.2kPa): Undetermined
7. Refractive index: Undetermined
8. Flashpoint (ºC): Undetermined
9. Specific optical rotation (º): Undetermined
10. Autoignition point or ignition temperature (ºC): Undetermined
11. Vapor pressure (kPa,25ºC): Undetermined
12. Saturated vapor pressure (kPa,60ºC): Undetermined
13. Heat of combustion (KJ/mol): Undetermined
14. Critical temperature (ºC): Undetermined
15. Critical pressure (KPa): Undetermined
16. Oil and water (octanol/Log value of partition coefficient for water: undetermined
17. Explosion limit (%,V/V): Undetermined
18. Lower explosion limit (%,V/V): Undetermined
19. Solubility:Soluble in acetone, methanol, dimethylformamide, slightly soluble in ethanol, insoluble in water
Toxicological data
None
Ecological data
None
Molecular structure data
1. Molar refractive index: 75.76
2. Molar volume (m3/mol ): 205.8
3. isotonic specific volume (90.2K):606.2
4. Surface Tension (dyne/cm):75.2
5. Polarizability（10-24cm3):30.03
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 3
3. Number of hydrogen bond acceptors: 7
4. Number of rotatable chemical bonds: 5
5. Number of tautomers: 4
6. Topological molecule polar surface area 131
7. Number of heavy atoms: 21
8. Surface charge: 0
9. Complexity: 481
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None
Storage method
This product should be sealed and stored in a cool, dry place.
Synthesis method
From 2, 4-dichlorobenzoic acid (see 12740) through chlorosulfonation, ammoniation and acidification to obtain 2, 4-dichloro-5-Sulfamoyl benzoic acid is then condensed with furfurylamine to produce furosemide.
Purpose
This product has a strong but short-lived diuretic effect. It is a powerful diuretic and is used to treat edema caused by heart, liver, kidney and other diseases. , especially in cases where base diuretics are ineffective; it can be used to treat acute pulmonary edema, cerebral edema, acute renal failure, hypertension and other diseases; combined with rehydration, this product can promote the non-excretion of poisons.
extended-reading:https://www.newtopchem.com/archives/555extended-reading:https://www.bdmaee.net/dabco-eg-33-triethylenediamine-in-eg-solution-pc-cat-td-33eg/extended-reading:https://www.bdmaee.net/dabco-mp602-delayed-amine-catalyst-non-emission-amine-catalyst/extended-reading:https://www.morpholine.org/n-acetylmorpholine/extended-reading:https://www.cyclohexylamine.net/delayed-catalyst-for-foaming-dabco-dc2-polyurethane-catalyst-dabco-dc2/extended-reading:https://www.bdmaee.net/wp-content/uploads/2022/08/115-8.jpgextended-reading:https://www.bdmaee.net/n-n-dimethyl-ethanolamine/extended-reading:https://www.newtopchem.com/archives/685extended-reading:https://www.cyclohexylamine.net/dabco-ne600-no-emission-amine-catalyst/extended-reading:https://www.cyclohexylamine.net/high-quality-bis2dimethylaminoethylether-22%e2%80%b2-oxybisnn-dimethylethylamine-cas-3033-62-3-bdmaee/
